In this study, we employed unbiased lipidomic and transcriptomic approaches to investigate the contribution of IRE1α signalling to lipid metabolism in TNBC. This system biology framework enables the ...

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Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China National Center of Technology ...

1Hummingbird Bioscience Pte Ltd, Singapore, Singapore.

Intracerebral Hemorrhage (ICH) is a destructive neurovascular disease with no efficient treatment. Trapped Red Blood Cells (RBCs) in the brain lyse releasing toxic heme from hemoglobin. Heme, a ...

Introduction: PAH is associated with loss of pulmonary microvessels & vascular remodeling. Metabolic reprogramming(MR) characterized by high glycolysis & reduced FAO is hallmark feature of PAH linked ...

A recent publication in Cell demonstrates that arginine, an amino acid that facilitates various cellular processes, including cellular growth, also promotes tumor growth. The study shows that arginine ...

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Signaling rewiring allows tumors survive therapy. Here we show that the decrease of the master regulator microphthalmia transcription factor (MITF) in lethal prostate cancer (PCa) unleashes eukaryotic ...

In the hunt for new antibiotics, people have looked in myriad locations. At the University of Pennsylvania, Cesar de la Fuente’s team goes hunting in the protein world. The researchers aim to find ...