While mechanisms controlling uncoupling protein-1 (UCP1) in thermogenic adipocytes play a pivotal role in non-shivering thermogenesis, it remains unclear whether F 1 Fo-ATP synthase function is also ...

The study illuminates how the ATP synthase operates under hypoxic conditions. “To understand the mechanism of action of drugs or to design drugs that target molecular machines, it is important to ...

Exome analysis revealed a de novo heterozygous variant in ATP5F1B, which encodes the β subunit of mitochondrial ATP synthase (also ... of the ovine complex V structure (Protein Data Bank ...

A new discovery related to the mechanism of the danger signal adenosine triphosphate could influence how immunomodulators, such as vaccines and allergy medications, are formulated. The team began with ...

Many of these diseases are tied to a deficiency in ATP synthase thought to be triggered by mutations ... assimilation and ultimately forming cobalt nanoparticles in the fungal structure. In this way, ...

These new roles for the enzyme reinforce earlier estimations that the true efficiency of ATP synthase is around 90%. Sunil Nath, a senior researcher at the Indian Institute of Technology Delhi who ...

Mitochondria are the powerhouses of eukaryotic cells. Pairs of molecular machines with a rotary action, called ATP synthase, are embedded in their inner membranes and produce adenosine triphosphate, ...

Two newly published cryo-EM studies by Kock-Flygaard et al and Mühleip et al from Alexey Amunts lab, identify different types of ATP synthase organization. The structure of the ATP synthase from ...