Animal studies have established the previously unknown role of a protein that helps activate brown fat, a tissue that can ...

Kelly-Anne Phillips, Joanne Kotsopoulos, Susan Domchek, Mary Beth Terry, James Chamberlain, Julie Bassett, Amber Aeilts, Irene Andrulis, Saundra Buys, Wanda Cui, Mary ...

This paper investigates how isoform II of transcription factor RUNX2 promotes cell survival and proliferation in oral squamous cell carcinoma cell lines. The authors used gain and loss of function ...

Poly (ADP-ribose) polymerase (PARP) inhibitors: These are used for people whose prostate cancer cells have mutations in certain genes, like BRCA1 or BRCA2. These gene changes make it harder for the ...

As a BRCA1 carrier, I have a 44 per cent lifetime risk of developing the same dreaded ovarian cancer that killed my mother. Women diagnosed with ovarian cancer have the poorest prognosis of all ...

For example, some families have a change in the BAP1 gene that increases their risk for eye melanoma. This mutation affects only a small number of people, but studying it could help researchers learn ...

This condition is caused by an inherited mutation (change) in the BAP1 gene. Cancers linked with this syndrome tend to be aggressive and often appear at younger ages. An eye condition known as primary ...