Novel combination achieves 60.8% response rate and 90.2% disease control rate in first-line non-small cell lung cancer (1L ...

To enhance CAR T therapies, scientists are actively studying TCR signaling and T-cell exhaustion mechanisms to improve CAR T ...

The different phenotypical and functional profiles of HBV core-specific and HBV pol-specific CD8 + T cell responses were not influenced by different HBsAg or HBcrAg levels. CD4 + and CD8 + T cells ...

Complementary nature of these two immunotherapies leads to excellent 17.6-month median Overall Survival in head and neck cancer patients with PD-L1 CPS 1; Mature overall survival ...

When the immune system becomes activated by a virus such as HIV, part of the response includes the release of CD4 cells. Also known as helper cells, their role is to trigger the release of another ...

CD4+ and CD8+ T cells accumulate in the skin of patients with psoriasis. These cells are also identified by markers of activation (e.g., increased IL-2 receptors and HLA-DR surface molecules) and ...

We were able to describe the canonical development of conventional CD4 T cells and CD8 T cells from their progenitors in the thymus to effectors in peripheral blood. We also found trajectories leading ...

et al. Influence of lifelong cumulative HIV viremia on the long-term recovery of CD4+ count and CD4+/CD8+ ratio among patients on combination antiretroviral therapy. AIDS. 2015;29(5):595-607. DOI: ...

Biomarkers such as CD4, CD8, PD-L1, FOXP3, and CK AE1/3 are critical for understanding T-cell biology and tumor-immune interactions. Traditional immunofluorescence (IF) and immunohistochemistry (IHC) ...

This study presents a useful reassessment of the potential role of dendritic cell-derived IL-27 p28 cytokine in the functional maturation of CD4+CD8- thymocytes, and CD4+ recent thymic emigrants. The ...