Methods: In this prospective study, HIV-positive individuals at antiretroviral therapy (ART) clinics were screened for latent tuberculosis infection (LTBI) before starting isoniazid (INH) prophylaxis.

In healthy cells, cyclin D1 is expressed during the G1 phase of the cell cycle, where it activates CDK4 and CDK6. Its dysregulation is a well-established oncogenic driver in numerous human cancers.

Version of Record: This is the final version of the article. García-Vázquez et al. identify GTSE1 as a novel target of the cyclin D1-CDK4/6 kinases. The authors show that GTSE1 is phosphorylated at ...

DEER ISLE — The former Island Nursing Home is going to be transformed into 23 one-bedroom apartments for older adults and those working on the island, the board announced Tuesday. There will be ...

The trial evaluated the efficacy of imlunestrant, an oral selective estrogen receptor degrader (SERD), compared with fulvestrant (Faslodex) in patients who had previously been treated with CDK4/6 ...

Meihua Li and Apeng Liang contributed equally to this work. FDA approved CDK4/6 inhibition medicines has demonstrated significant clinical benefits in patients with HR+/HER2- breast cancer. However, ...

CDK4/6 inhibitors (CDK4/6i) have revolutionized HR+ metastatic breast cancer treatment. Trials like PALOMA, MONALEESA, and MONARCH showed improved progression-free survival (PFS) with endocrine ...

The perinephric myxoid pseudotumor of fat (PMPF) is an uncommon benign neoplasm characterized by a favorable prognosis. To date, 21 cases of PMPFs have been reported worldwide, and their detailed ...

Clinical Benefit and Safety of Reduced Elective Dose in Definitive Radiotherapy for Head and Neck Squamous Cell Carcinoma: The UPGRADE-RT Multicenter Randomized Controlled Trial The following ...

The results of our analysis suggest that INH prophylaxis reduces the risk of TB by 59% among children ≤ 15 years of age, excluding a subset of young children on whom INH was initiated at ...