Cyclin D1–CDK4/6 phosphorylates GTSE1 in cancer cells, preventing its degradation and sustaining high levels across the cell cycle, which enhances proliferation and correlates with poor prognosis.

Despite substantial advances in cancer therapeutics, the near inevitable emergence of treatment resistance limits overall survival of advanced cancer patients. Genomic drivers of intrinsic and ...

1Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2Division of Life Sciences and Medicine, Department of Urology, the First Affiliated ...

Masturbation is a normal and healthy part of sexual expression. However, if it becomes compulsive, there are many ways a person can stop masturbating, such as exercising and avoiding pornography ...

On’s signature lifestyle shoe is perfect for those who want a sneaker that can handle their hybrid lifestyle.

Colorectal cancer (CRC), or bowel cancer, includes colon cancer and rectal cancer. It involves the uncontrolled growth and division of cells in the colon or rectum. The colon is the longest ...

John Lennon and Yoko Ono's son, Sean Ono Lennon, has opened up about his parents' 'co-dependent' relationship. The 49-year-old musician claimed that his parents had "fused into one person" before ...

We thank A.J. Hudspeth and Tri-Institutional Therapeutic Discovery Institute for codeveloping the TDI-011536 Lats kinase Inhibitor utilized in this study. We thank Dr. Renjie Chai and Dr. Joe Burns ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Locusts, as devastating pests, can reversibly ...

Finally, changes are here! This week’s horoscope is lit! The Sun in Aries harmonizes with Jupiter in Gemini on April 6, heightening our ego and desires. A few hours later, Venus retrograde in ...