To support commercial supply readiness, Cabaletta has been advancing BLA-enabling activities for our lentiviral vector process at Oxford Biomedica and implementing the planned commercial drug product ...

With commercial real estate-backed collateralized loan obligations (CRE CLOs) under intense scrutiny, CRED iQ’s issuer rankings reveal key shifts in risk and opportunity. CRED iQ’s latest quarterly ...

The global lentiviral vector CDMO market is set to witness a growth rate of 8% in the next 5 years. Growing demand for gene and cell therapies; expanding pipeline of gene therapy products; ...

Lentiviral transduction is a popular and powerful gene delivery method for downstream applications such as cell line generation, therapeutic model generation and CAR-T research. However, current ...

AstraZeneca has entered the “off-the-shelf” cell therapy space, penning a $1 billion deal to acquire EsoBiotec and its lentiviral vector platform. The deal will see AstraZeneca scoop up all ...

SAN DIEGO -- Results from a small single-center study showed that treatment with a gene therapy involving the use of lentiviral vector-transduced autologous hematopoietic stem cells (HSCs ...

To produce lentivirus, psPAX2, pMD2G and pLKO ... Here, we generated an L cell-specific Cre mouse line for the first time by combination of the Flp-Frt and Cre-LoxP systems, which allows genetic ...

Cerebral adrenoleukodystrophy is a severe form of X-linked adrenoleukodystrophy characterized by white-matter disease, loss of neurologic function, and early death. Elivaldogene autotemcel (eli ...

and to further develop its proprietary lentiviral vectors. The vectors are designed to be applicable to a range of liver-related metabolic disorders and, as its first indication, the company intends ...

The study reported two new mouse genetic tools, namely Myh11-Cre and Myh11-CreER. These innovative tools can specifically label smooth muscle cells (SMCs) irrespective of gender and surpass the ...

The LV Edge Packaging System has recently been launched to improve cost efficiency and reduce the supply chain risk of lentiviral production. The company claims the ready-to-transfer system ...

This enables lentiviral production from a single-plasmid transfection, in contrast to the standard four-plasmid process. In lentiviral manufacturing, GMP plasmids account for a substantial ...