“PDI is like a double agent,” Dr Shadfar explains. “In healthy cells, it repairs DNA and helps prevent disease. But in cancer ...

New study shows RNA polymerase I halts at abasic DNA damage, helping prevent faulty rRNA production and exposing lesions for ...

For decades, scientists have studied how to control DNA—the molecule that holds the instructions for all life. One of the ...

As a postdoc, Komor found a way to achieve gene-editing with higher efficiencies and a lower incidence of indels by avoiding double-stranded breaks. She called this new class of tools “base editing” ...

The personalized CRISPR treatment could be the future of gene therapy, but hurdles remain before everyone has access.

Throughout the course of our lives, DNA can break in response to natural and environmental factors. However, our bodies have dedicated enzymes and pathways which can repair our broken DNA back ...

Etoposide works by breaking DNA strands and blocking an enzyme which helps repair the damage. Surprisingly, inducing DNA damage resulted in reactive oxygen species being generated and accumulating ...

Scientists at the Francis Crick Institute, in collaboration with Artios, have identified how an enzyme involved in DNA repair (POLQ), becomes vital to the survival of certain cancers, if the ...

The x-ray structure of a DNA repair enzyme in the process of searching for damaged DNA bases illuminates a long-standing puzzle. "This structure provides a glimpse at how a DNA repair enzyme ...

In the search for urgently needed new drug targets to exploit DNA repair deficiencies, the team studied the effect of removing ALC1, an enzyme which plays an important role in repair of damaged ...

In the search for urgently needed new drug targets to exploit DNA repair deficiencies, the team studied the effect of removing ALC1, an enzyme which plays an important role in repair of damaged ...