At the heart of the acquisition is Regulus’ farabursen, an miRNA-targeting oligonucleotide in early-stage development for rare autosomal dominant polycystic kidney disease. Novartis is buying Regulus ...

The longer form of the RNA produced from a microRNA gene acts as a precursor. It's able to fold over and base-pair with itself, forming a structure called a hairpin. An enzyme called Dicer ...

Major Dicer‐dependent mechanisms are RNA interference (RNAi) and microRNA (miRNA) pathways, which employ distinct types of small RNAs. Small interfering RNAs (siRNAs) for RNAi are produced by Dicer ...

4-Hydroxynonenal (4-HNE) is a major byproduct of lipid peroxidation, a process exacerbated by mitochondrial dysfunction and oxidative stress. Accumulation of 4-HNE protein adducts has been reported in ...

This means that when Dicer cleaves precursor RNA molecules to produce miRNA, it can use landmarks (cis-regulatory elements) within the RNA to know precisely where to cut. This mechanism allows ...

In animals, the enzyme Drosha conducts the first cut and Dicer the second. Both enzymes define the ends of a short double-stranded miRNA intermediate from which one miRNA strand is selected and ...

The accuracy of miRNA sequences and expression is mainly determined by miRNA biogenesis, a process which involves DICER cleaving miRNA precursors (pre-miRNAs) to generate miRNAs. Therefore ...

Previously we showed that human Drosha and Dicer ribonucleases (RNases) both discriminate their respective microRNA (miRNA) substrates, and that differential cleavage by Drosha contributes to global ...

The level of microRNA expression in these mice changed their survival rates. If circ2082 was knocked down, the nuclear DICER complex of circ2082, DICER, and RBM3 was disrupted, more microRNAs were ...

The level of microRNA expression in these mice changed their survival rates. If circ2082 was knocked down, the nuclear DICER complex of circ2082, DICER, and RBM3 was disrupted, more microRNAs were ...