ABSTRACT: Mutagens are agents that cause damage to DNA and have the potential to permanently alter (mutate) its sequence, depending on the organism’s ability to repair the damage. UV radiation is a ...

This study reveals a novel role of TET2 in regulating gluconeogenesis. It shows that fasting and a high-fat diet increase TET2 expression in mice, and TET2 knockout reduces glucose production. The ...

In patients, the glucose synthesis pathway in the liver (gluconeogenesis) is hyperactivated, a process that can be controlled by drugs such as metformin. "Recently, new factors involved in the ...

Pyruvate is then converted to glucose by gluconeogenesis. In muscle cells, lactate is produced from glucose metabolism under anaerobic conditions. Lactate enters the bloodstream and is carried to the ...

In this study, we found that COVID-19 is independently associated with in-hospital hyperglycemia and that SARS-CoV-2 is capable of infecting hepatocytes and stimulate these cells to produce glucose ...

When a person’s blood glucose levels fall, pancreatic cells secrete glucagon, stimulating two processes: gluconeogenesis and glycogenolysis. The liver provides or stimulates the production of ...

The Cori cycle transports the lactate byproduct to the liver where it is processed and recycled to glucose through a process called gluconeogenesis. Once this process takes place, the muscles can then ...

In this study, we aimed to find out how the sperm tsRNA involved in paternal high-fat diet induced abnormal gluconeogenesis of F1 offspring, and explore the underlying molecular mechanism of its ...

“We started with physiological studies in humans and demonstrated that the major effect of metformin is to decrease hepatic gluconeogenesis.” Type 2 diabetes impairs the way that the body regulates ...

Lag times between glycolysis and gluconeogenesis show asymmetry in many microbes: a long lag in one direction, but a short lag in the other. Long lag times are caused by an inability to sense fluxes ...