Acute lymphocytic leukaemia (ALL) is a cancer of the blood and bone marrow, specifically affecting lymphocytes. The disease progresses rapidly and creates immature blood cells, rather than mature ...

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The small molecules in question are ASTX029, an ERK1/2 inhibitor that has completed a phase 2 study, and ASTX295 an MDM2 antagonist that has undergone a phase 1 trial. Both candidates have ...

Therefore, reactivating this pathway represents a potential therapeutic strategy. p53 is tightly regulated by MDM2 and MDMX which are frequently elevated in ccRCC patients. However, the molecular ...

None of the cases exhibited positive IgG4 plasma cells or MDM2 amplification. Table 1. Clinicopathologic features of all reported cases of the perinephric myxoid pseudotumors of fat. At present, the ...

Male choriocarcinoma is an extremely rare malignant tumor. It has the characteristics of hidden onset, easy invasion and metastasis. Clinically, when choriocarcinoma is found in a patient, most of the ...

It focuses on its lead product candidate, ALRN-6924, which is a cell-permeating peptide that disrupts the interaction of p53 suppressors MDM2 and MDMX with tumor suppressor p53 to reactivate tumor ...