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Physician's Weekly17d
Mechanistic insights into proteasome inhibitor MG132 induced apoptosis in melanoma A375 cells.
Despite advancements in melanoma therapy, the prognosis remains unfavorable for many patients. The proteasome inhibitor MG132 has shown therapeutic potential through pathway regulation, yet its ...
FierceBiotech20d
Mosaic adds to cancer combo pattern by licensing 2 clinical-stage drugs from Astex
The small molecules in question are ASTX029, an ERK1/2 inhibitor that has completed a phase 2 study, and ASTX295 an MDM2 antagonist that has undergone a phase 1 trial. Both candidates have ...
Frontiers21d
Combinatorial biosynthesis of novel gentamicin derivatives with nonsense mutation readthrough activity and low cytotoxicity
Moreover, GK-Ae increased the levels of both p53 and its downstream targets p21 and BAX, and promoted apoptosis of cancer cells. Conclusion: These results demonstrate the potential of combinatorial ...
philstar.com22d
PAL taps British aviation expert as new president
In 2024, PAL recorded its fourth consecutive year of profitable operations with a net income of P10.2 billion, although this marked a 51 percent decline from its record-high net income of P21 ...
eLife28d
Δ133p53α and Δ160p53α isoforms of the tumor suppressor protein p53 exert dominant-negative effect primarily by co-aggregation
The presence of Δ133p53 or Δ160p53 significantly reduced the binding of FLp53 to the p21 promoter, which has the highest affinity for FLp53, while having minimal impact on its interaction with the ...
eLife28d
Δ133p53α and Δ160p53α isoforms of the tumor suppressor protein p53 exert dominant-negative effect primarily by co-aggregation
Department of Cell and Molecular Biology, Uppsala University, Biomedical Center, Uppsala, Sweden Department of Medical Biochemistry and Microbiology, Uppsala University, Biomedical Center, Uppsala, ...
C&EN1mon
Modulation of Gene Expression by Substrate Stiffness via Ubiquitination of Histone H2B by Ubiquitin-Conjugating Enzyme E2A/B
School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin 300072, China ...
Frontiers2y
Tubeimoside-1: A review of its antitumor effects, pharmacokinetics, toxicity, and targeting preparations
Furthermore, TBMS-1-induced molecular events were associated with mitochondria-induced intrinsic apoptosis and p21/cyclin B1/cell division cycle 2 (p21/Cyc B1/cdc2) complex-related G2/M cell cycle ...