Mechanistically, NR2F1 directly interacts with the STAT3 promoter, resulting in its transcription. In turn, STAT3 promotes fibrosis and enhances lens epithelial cell migration and apoptosis ...

Result: In this study, we predicted potential targets for β-BA using public databases and identified 29 key genes, with STAT3 being the most significant. GO analysis revealed that these targets are ...

The small molecules in question are ASTX029, an ERK1/2 inhibitor that has completed a phase 2 study, and ASTX295 an MDM2 antagonist that has undergone a phase 1 trial. Both candidates have ...

either by inducing the degradation of MDM2, a negative regulator of p53, or by reducing histone deacetylase 1. Furthermore, PTL is a potent inhibitor of STAT proteins, blocking STAT3 phosphorylation ...

Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China Correspondence to: Dr. Guang Ji, Institute of Digestive Diseases, Longhua ...