The small molecules in question are ASTX029, an ERK1/2 inhibitor that has completed a phase 2 study, and ASTX295 an MDM2 antagonist that has undergone a phase 1 trial. Both candidates have ...

In healthy cells, cyclin D1 is expressed during the G1 phase of the cell cycle, where it activates CDK4 and CDK6. Its dysregulation is a well-established oncogenic driver in numerous human cancers.

Chemistry Department, School of Life Sciences, University of Sussex, Brighton BN1 9QJ, U.K. Bio-Techne (Tocris), The Watkins Building, Atlantic Road, Avonmouth ...

None of the cases exhibited positive IgG4 plasma cells or MDM2 amplification. Table 1. Clinicopathologic features of all reported cases of the perinephric myxoid pseudotumors of fat. At present, the ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Centrosomes are tubulin-based organelles that ...

Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Max von Laue Str. 9, 60438 Frankfurt am Main, Germany Structural Genomics Consortium, Buchmann Institute for Molecular Life ...

Schaffer describes browsing the U2OS cell map as similar to navigating an online geographical map. “You’re able to really explore, zoom in, and see what proteins are part of these different ...

HT-29 and HT-29 derived lines were maintained in McCoy’s 5A + 10% FBS + 1X Penicillin-Streptomycin. U2OS 2-6-3 cells were grown in full DMEM supplemented with 10% FBS, penicillin-streptomycin and ...