Overall, a higher risk of metachronous colorectal cancer was found to be higher among patients who underwent segmental ...

In patients of Lynch syndrome—an inherited condition -- risk of developing a second tumour could be lower among those having ...

An international study suggests that patients with Lynch syndrome, an inherited condition increasing cancer risk, may benefit ...

Ahmedabad: A global research comprising of 8,438 patients suffering from colorectal cancer caused by Lynch Syndrome has ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. During meiosis, at least one crossover is ...

EXO1 has a structural role to promote the MLH1-MLH3 nuclease complex to process meiotic recombination intermediates into crossovers. Here, the authors demonstrate that EXO1 function depends on ...

Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou, Guangdong 510055, China Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-Sen University, ...

From 95 Lynch syndrome families, we selected all carriers of a germline mutation in the MSH2, MLH1 or MSH6 gene, who had been seen and registered at the Department of Human Genetics of the Radboud ...

We performed a bioinformatic analysis that implicated Saccharomyces cerevisiae Rad5 as a candidate for interacting with the MMR proteins Msh2 and Mlh1. Rad5 is a DNA helicase and E3 ubiquitin ligase ...