Lavish Mohan Paryani, along with his alleged accomplice Reigna Reyes, was ordered arrested by the Regional Trial Court (RTC) of Marikina City in connection with a P16-million estafa complaint filed by ...

In healthy cells, cyclin D1 is expressed during the G1 phase of the cell cycle, where it activates CDK4 and CDK6. Its dysregulation is a well-established oncogenic driver in numerous human cancers.

Version of Record: This is the final version of the article. García-Vázquez et al. identify GTSE1 as a novel target of the cyclin D1-CDK4/6 kinases. The authors show that GTSE1 is phosphorylated at ...

in the January to March period by 9 percent to P16.6 billion, with the company already expecting to exceed its full-year earnings record. BPI president Jose Teodoro Limcaoco confirmed to reporters ...

The trial evaluated the efficacy of imlunestrant, an oral selective estrogen receptor degrader (SERD), compared with fulvestrant (Faslodex) in patients who had previously been treated with CDK4/6 ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Protein Kinase A (PKA) is regulated spatially ...

Meihua Li and Apeng Liang contributed equally to this work. FDA approved CDK4/6 inhibition medicines has demonstrated significant clinical benefits in patients with HR+/HER2- breast cancer. However, ...

CDK4/6 inhibitors have been approved for the treatment of metastatic ER+ and HER2- breast cancer. However, patients will become resistance due to various mechanisms, resulting in high unmet need.

The table below is a review of notable updates that occurred in March 2025 for investigational products in development (not an inclusive list). Click on the status to view our full coverage.