The role of EGFR in KRASG12D-driven tumorigenesis was studied using mouse CRC organoids with KRAS-APC-TP53 mutations and ...

We are investigating the mechanisms by which cancer mutations deregulate the normal processes of cellular function and growth ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Cells change their metabolic profiles in ...

State Key Laboratory of Polymer Science and Technology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China Key Laboratory of Polymer Ecomaterials, Changchun ...

Depending on their histopathological characteristics and proliferative potential, precancerous lesions of the FT are categorized as p53 signatures, Serous Tubal Intraepithelial Lesions (STILs) or ...

Major Finding: Dietary ω-6 linoleic acid (LA) promotes oncogenic mTOR signaling in triple-negative breast cancer (TNBC). Concept: TNBCs express the fatty acid binding protein FABP5, which senses ω-6 ...

This important study investigates the molecular mechanisms by which the p53 isoforms Δ133p53α and Δ160p53α exert dominant-negative effects on full-length p53 (FLp53). Through a combination of ...

PTL targets key signaling pathways to combat malignancy, inhibiting NF-κB and signal transducer and STAT3, promoting ROS production, and activating p53. These mechanisms contribute to its ...