A 35-year-old man presents with a chief complaint of purple discoloration of his toes and associated skin lesions that have been present for the past month.

Merck Presents Positive Phase 2 Data for Enpatoran Demonstrating Reduction in Disease Activity in Patients with Cutaneous Lupus Erythematosus (CLE) and Systemic Lupus Erythematosus (SLE) with Active L ...

WILLOW is a global, multicenter, randomized, placebo-controlled Phase 2 study evaluating three doses of enpatoran taken twice daily (25 mg, 50 mg and 100 mg) versus placebo plus standard of care (SoC) ...

Numerous autoimmune diseases are associated with the development of age-related macular degeneration (AMD), according to ...

Cohort analyses from the WILLOW study reveal clear proof of concept in patients with CLE and SLE with active lupus rash, showing clinically meaningful ...

Antibodies targeting the TFAM protein could increase the risk of blood clotting complications in people with lupus, a study ...

Circulating DCs are decreased in SLE; this is thought to be due to enhanced migration into peripheral affected tissues. While there is variability between in vitro studies, SLE DCs exhibit an ...

The following is a summary of “Systemic lupus erythematosus: updated insights on the pathogenesis, diagnosis, prevention and therapeutics,” published in the March 2025 issue of Signal Transduction And ...

This is a continuing challenge in systemic lupus erythematosus (SLE), a chronic autoimmune disorder whose pathophysiology involves a complex network of dysregulated elements of the immune system ...

Epidemiological studies are essential to understand the overall burden of a disease, make policy decisions on healthcare utilization and cost and examine and mitigate disparities of disease burden.

A new study published in Lupus Science & Medicine found a new diagnostic and disease activity monitoring biomarker for systemic lupus erythematosus (SLE) which could help understand pathogenesis, ...

The combined findings of our in vitro model and the analysis of the patient biopsies indicate that SLE pathogenesis involves epithelial cells and could potentially weaken the structural integrity of ...