Topline results from the chronic cohort of an ongoing phase 1b/2a clinical trial of an investigational therapeutic peptide, NVG-291, found the novel treatment led to increased electrical connectivity ...

The first synapses of the pain pathway are concentrated in the superficial spinal cord dorsal horn. Here peripheral inputs are processed by local interneuron circuitry before ascending to the brain.

Afferent signaling from cardiopulmonary neurons through dorsal root ganglia (DRG) to the dorsal horn of thoracic spinal cord mediated via TRPV1 and SP results in transcriptomic remodeling ...

Abstract: The spinal cord dorsal horn is a relay hub that receives sensory information from the peripheral nervous system and transmits bioelectrical signals to the brain. In vivo imaging of neuronal ...

They discovered that over 90 percent of neurons in the dorsal horn - the sensory processing area of the spinal cord - responded to light touch. "This was surprising because classically it was ...

Methods: Adeno-associated viruses (AAVs) carrying channelrhodopsin-2 (ChR2, a blue-light sensitive ion channel) CaMKIIα-hChR2(H134R) or empty vector were injected into the dorsal horn of the T1 spinal ...

Projection neurons of the spinal cord dorsal horn which transmit pain, itch and temperature information to the brain comprise the anterolateral system (AS). A recent molecular and genetic study showed ...

The pain experience depends on the relay of nociceptive signals from the spinal cord dorsal horn to higher brain centers. This function is ultimately achieved by the output of a small population of ...

which enter the spinal cord via the dorsal root. Some of these nerve fibers form connections with other nerves in the dorsal horn, whereas some fibers directly continue up to the brain.