We previously described a hepatocyte growth factor–induced memory T cell subset that preferentially migrates to the heart. 15 These T cells are characterized by expression of the hepatocyte growth ...

Researchers at the University of Michigan designed an optimized viral protein able to boost the antitumor function of T cells. The project stemmed from observations on the particular system employed ...

In a new study published in Cell Genomics, researchers use RNA sequencing to characterize bone metastases from eight cancer ...

In recent years, the therapeutic landscape for hematological malignancies has undergone a profound transformation, driven by ...

Immunologists from the Institute have been the first to uncover a role for a family of RNA binding proteins in the function ...

The body defends itself against pathogens by depriving them of vital iron. However, this strategy doesn't always succeed ...

Scientists say study findings indicate that TC IV cells may represent a therapeutic target for the treatment of ...

Simultaneous expansion and activation of both major γδ T cell subsets (Vδ1+ and Vδ2+) leverages both the rapid antigen presenting properties of Vδ2+ T cells and the longer-term resistance against ...

CD4+ T cell subsets exhibit distinct surface molecules, cytokines, and key transcription factor expressions, including Th1, Th2, Treg, Tfh, Th17, Th9, Th22, and CD4+ cytotoxic T lymphocytes (CTL) [14] ...

Bicistronic CD19/CD22-directed CAR-T cell therapy achieved high remission rates and durable responses in pediatric B-ALL patients. One-year EFS and OS rates were 75.5% and 93.5%, respectively, with ...

However, genetic ablation of LXRβ in T cells did not revert the effects of NCOR1 deficiency, indicating that NCOR1 controls naïve and effector Treg cell subset composition independent from its ability ...

aDivision of Neuroimmunology and Neurological Infections, Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, United States bInstitute for Clinical and Translational Research, ...