Myasthenia gravis (MG) is a rare, chronic autoimmune disorder that disrupts the communication between nerves and muscles. It ...

IL-3 receptor signalling counteracts experimental colitis. Mechanistically, IL-3 receptor signalling controls the mechanobiology of regulatory T cells (Tregs) and impedes mucosal Treg egress to ...

Americans are increasingly critical of Elon Musk’s role in the Trump administration, with a Washington Post-ABC News-Ipsos poll finding negative reactions to some cuts made by his U.S. DOGE ...

2015). These considerations account for the widespread interest in the development of IDO inhibitors to suppress Treg (and cancer cell) suppression of T effector cells consistent with data that mice ...

There are several types of CD4 T cells that serve different functions. They are commonly divided into conventional T helper (Th) cells and regulatory T (Treg) cells. Treg cells are tasked with ...

Modes of Action in Specific Immunotherapy The induction of CD4 + CD25 + Tregs leads to the production of anti-inflammatory cytokines such as IL-10 and TGF-β decreasing Th2 type inflammation in ...

Expert Rev Resp Med. 2012;6(6):683-704. The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with ...

Graduate School, Hebei University of Traditional Chinese Medicine, Shijiazhuang 050091, P. R. China Department of Spleen and Stomach, First Affiliated Hospital of Hebei University of Traditional ...

Imperial researchers showed that subcutaneous immunotherapy suppressed Th2-T cell-driven allergic ... to either immune deviation in favour of Th1 responses and/or the induction of a population of ...

Ultimately, by normalizing the maternal response to fetal antigens and the broader immune state (e.g. restoring the proper Th1/17:Treg/Th2 cell ratio), PreE pathogenesis may be interrupted. Despite ...

IL-17 and IL-22: A Double-Edged Sword for Pregnancy The Th1/Th2 paradigm has recently been expanded into the Th1/Th2/Th17 and regulatory T (Treg) cells paradigm (42), in which Th2 and T reg cells are ...