Shenzhen Zhongge Biotechnology Co. Ltd. has described proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase binding agent coupled to interleukin-1 receptor-associated ...

In neurodegenerative diseases such as Alzheimer's or Parkinson's, proteins accumulate in the body's cells, fold incorrectly and clump together to form larger aggregates. Normally, cells are able to ...

In neurodegenerative diseases such as Alzheimer's or Parkinson's, proteins accumulate in the body's cells, fold incorrectly ...

When the cellular waste disposal system goes on strike, this can have fatal consequences. A research team at the University ...

Co. Ltd. has divulged proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase binding moiety covalently linked to a tyrosine-protein phosphatase non-receptor type 2 (PTPN2; ...

How well our brain functions depends heavily on the performance of our nerve cells. That is why they are regularly checked for their proper function -- defective cell components are marked, disposed ...

Ubiquitination, an essential post-translational modification, controls various cellular functions by attaching ubiquitin to ...

Science writer Eldrian Tho visited this year’s conference held in Liverpool, where several Imperial researchers presented ...

Zebrafish lacking a functional muscle clock showed signs of premature aging at two years. They were shorter, weighed less, swam less frequently and at slower speeds.

Artificial exosomes can be designed to encapsulate and deliver therapeutic payloads, including drugs, genes, and proteins.

Samples enriched for proteins were analyzed by mass spectrometry. Figure 2. MARCHF7 and UBR5 were identified as E3 ubiquitin ligases involves in nsp16 protein degradation. A. Knockdown of MARCHF7 or ...