Treatment with an mTOR inhibitor in 6-month-old TRGL/Q175 mice normalized lysosome numbers, alleviated aggresome pathology, and reduced mHTT, p62, and ubiquitin levels. These findings suggest that ...

Crossing TRGL mice with a model of a neurodegenerative disease, the Q175 mouse model of HD, has enabled us to assess disease-related autophagy alterations in the Q175 and TRGL/Q175 models and their ...

The White House Correspondents' Association hosted its annual dinner in Washington, DC to recognize various journalists … Former White House Press Secretary Sean Spicer and former CNN Washington ...

Two important factors in relapse are MYCN amplification and intratumoral heterogeneity. MYCN, a transcription factor of the MYC family, is amplified in about 40% of high-risk NB cases and is ...

Writer Michael Wolff provided his behind-the-scenes look at President Trump's 2024 election. Politics and Prose Bookstore in Washington, D.C., hosted this event. Santa Clara University history ...

Major Finding: Dietary ω-6 linoleic acid (LA) promotes oncogenic mTOR signaling in triple-negative breast cancer (TNBC). Concept: TNBCs express the fatty acid binding protein FABP5, which senses ω-6 ...

Circular RNAs (circRNAs) have been gradually revealed to regulate the progression of heart disease in depth, showing their clinical significance. However, a mass of cardiac circRNAs still has not been ...

Furthermore, ART exhibited strong interactions with AKT1, a key molecule in the PI3K/AKT/mTOR signaling pathway, which was widely activated in various malignancies and promotes tumor cell survival and ...

Graduate School, Hebei University of Traditional Chinese Medicine, Shijiazhuang 050091, P. R. China Department of Spleen and Stomach, First Affiliated Hospital of Hebei University of Traditional ...