mimic miRNA, and antimiR. According to publications, high siRNA concentrations during transfection may result in non-specific off-target effects. Using as little siRNA as possible can improve the ...

Although siRNA/microRNA-based gene therapy has enormous potential, it is severely limited by the lack of specific cell-targeting delivery systems. We report an osteoblast-targeting peptide (SDSSD) ...

"Therapeutic siRNA drugs don't work well enough against ... for their joint discovery of microRNA and its role in gene regulation in the early 1990s. Dr. Lai did his undergraduate thesis research ...

However, the optimal pre-clinical method to target the Notch3 pathway effectively through Exo, miRNA, and siRNA remains to be assessed. Hypothesis: Exo are the most effective biologic to target the ...

The authors did not agree to this retraction. Citation: Frontiers Editorial Office (2024) Retraction: Multicomponent siRNA/miRNA-loaded modified mesoporous silica nanoparticles targeted bladder cancer ...

Unlike other RNA molecules such as mRNA, which carries genetic information for protein synthesis, or miRNA, which regulates gene expression more broadly, siRNA is designed to target and silence ...

miRNA-34a effectively acts “like the brakes ... were silenced to levels commonly observed following single-gene siRNA targeting.” These results, they suggested, indicate that “the chemical ...

Using both individual and combined siRNA(s) we showed that no individual 1B3 target reproduced the miRNA effect which suggests that multiple, simultaneous, gene repression by 1B3 is more effective ...

Figure 2. The guide strand of the siRNA or a miRNA is loaded into an Argonaute protein. In case of a perfect complementarity through siRNAs or miRNAs (which is often observed in plants), a ...