Silencing of Rictor or Akt1 in c-Myc HCC cell lines inhibited phosphorylated forkhead box o1 expression and strongly suppressed cell growth in vitro. In human HCC samples, c-MYC …

May 8, 2017 · Here we examined the role of Myc activation in mouse liver tumours induced by hepatocytic expression of myristoylated AKT (AKT) and/or mutant HRASV12 (HRAS) via …

The PI3K/AKT/c-MYC signalling axis is important in this context, since pharmacologic blockade of PI3K-AKT or siRNA knockdown of c-MYC effectively inhibited the RR phenotype and its …

Mar 3, 2010 · Activation of either Akt or c-Myc leads to the Warburg effect as indicated by increased cellular glucose uptake, glycolysis, and lactate generation. When cells are treated …

Jul 10, 2020 · Transcription factors of the MYC family are deregulated in up to 70% of all human cancers through a variety of mechanisms. Oncogenic levels of MYC regulates almost every …

Mar 5, 2010 · Here, we established a dual-regulatable FL5.12 pre-B cell line in which myristoylated Akt is expressed under the control of doxycycline, and c-Myc, fused to the …

Feb 17, 2025 · Loss of HNB leads to activation of RAS/MAPK signaling pathway, and enhances MYC stability by promoting phosphorylation of MYC at Ser 62. These findings identify PVT1 as …

Mar 21, 2013 · We now identify a direct mechanism by which Akt suppresses the proapoptotic effects of myc in which Akt up-regulates myc while simultaneously activating a Hunk …

Activation of either Akt or c-Myc leads to the Warburg effect as indicated by increased cellular glucose uptake, glycoly-sis, and lactate generation. When cells are treated with glycoly-sis …

May 4, 2016 · The PI3K/AKT/c-MYC pathway was revealed to mediate the stemness-promoting function of oxidative stress, and blockage of this pathway substantially decreased stem-like …