Cyclin-dependent kinase 4 (CDK4), also known as cell division protein kinase 4, is an enzyme that is encoded by the CDK4 gene in humans. CDK4 is a member of the cyclin-dependent kinase family, a group of serine/threonine kinases which regulate the cell cycle. [4]

This review discusses the role that CDK4 plays in cell cycle control, normal development and tumorigenesis as well as the current status and utility of approved small molecule CDK4/6 inhibitors that are currently being used as cancer therapeutics. Keywords: CDK4/6, cancer, cell cycle, targeted therapy, checkpoint inhibitor.

Mar 18, 2022 · Cyclin-dependent kinase 4 (CDK4) and CDK6 are critical mediators of cellular transition into S phase and are important for the initiation, growth and survival of many cancer types.

This review discusses the role that CDK4 plays in cell cycle control, normal development, and tumorigenesis as well as how small molecule inhibitors of CDK4 can be used to treat disease. Keywords: CDK4, cancer, cell cycle, knockout, targeted therapy.

3 days ago · Use MDM2 and CDK4 coexpression to help diagnose low grade osteosarcomas and high grade osteosarcomas that progressed from low grade osteosarcomas (Am J Surg Pathol 2010;34:1361)

In this Review, Fassl et al. discuss basic biology of CDK4 and CDK6 kinases, studies that led to identification of CDK4/6 as excellent anti-cancer targets, the growing application of CDK4/6 inhibitors in cancer treatment and the promise these compounds hold for future therapies.

Mar 30, 2025 · Complete information for CDK4 gene (Protein Coding), Cyclin Dependent Kinase 4, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

Jan 30, 2025 · Cyclin-dependent kinases (CDKs) 4 and 6 (CDK4/6) are important regulators of the cell cycle. Selective CDK4/6 small-molecule inhibitors have shown clinical activity in hormonal...

CDK4 signaling appears to act as a molecular switch from syngenic differentiation to neural transdifferentiation of human Multipotent mesenchymal stromal cells. CDK4 could provide a clinical prognostic marker for hepatocellular carcinoma progression.

The Cyclin D/Cdk4 complex is a multi-protein structure consisting of the proteins Cyclin D and cyclin-dependent kinase 4, or Cdk4, a serine-threonine kinase. This complex is one of many cyclin/cyclin-dependent kinase complexes that are the "hearts of the cell-cycle control system" [1] and govern the cell cycle and its progression.