Jan 25, 2024 · According to the LAST Project working group recommendations, p16 immunohistochemistry is recommended in all of the following clinical scenarios involving anogenital squamous lesions, EXCEPT: Routinely in the evaluation of biopsies with interpretations of negative, CIN I or CIN III

P16 immunostaining can be both positive and negative. P16 or INK4A immunostain is a strong indicator. It is used for high-risk-HPV associated dysplasias and oropharyngeal carcinomas.

P16 is a commonly used IHC marker; however, its interpretation is unique in the context of HPV-related lower anogenital lesions. Both quality and quantity of p16 immunoreactivity affect its specificity in predicting high-risk HPV and HSIL outcomes.

Mar 17, 2025 · p16 immunohistochemistry (IHC) is widely used in pathology to assess protein expression and its clinical implications, particularly in cancer diagnostics. This technique identifies aberrant p16 expression patterns linked to tumorigenesis, guiding prognosis and …

IHC expression of p16 can be used as a surrogate marker of HPV. Study of p16 expression may provide clinicians with more exact information in order to evaluate tumor aggressiveness, treatment modalities and can provide support for vaccination program in a high-risk group.

Introduction: p16 INK4a immunohistochemistry (IHC) is widely used to facilitate the diagnosis of human papillomavirus (HPV)-associated neoplasia, when ≥70% of cells show strong nuclear and cytoplasmic positivity.

Apr 3, 2025 · Among those tools, p16 immunohistochemistry (IHC) is used to diagnose challenging melanocytic tumors, with a negative result suggesting malignancy. p16, a tumor-suppressor protein encoded by the ...

Jun 16, 2017 · p16 immunohistochemistry has become the recommended standalone prognostic test for patients with oropharyngeal squamous cell carcinoma as it is more cost-effective and less technically...

cervical lesions is detectable by p16 IHC (Figure 2). The vast majority of high-grade CIN lesions will demonstrate positive p16 IHC staining (ie, positive CINtec ® Histology status).

Oct 27, 2020 · A surrogate marker of high-risk HPV, p16 has the ability to help discriminate and identify subtle dysplasias/malignancies in often fragmented, miniscule cervical biopsy specimens. This immunohistochemical (IHC) stain has been an …