<link rel="stylesheet" href="styles.8645b11ac6a93e53.css">

p21 is a potent cyclin-dependent kinase inhibitor (CKI). The p21 (CIP1/WAF1) protein binds to and inhibits the activity of cyclin-CDK2, -CDK1, and -CDK4 /6 complexes, and thus functions as a regulator of cell cycle progression at G 1 and S phase.

One of the main engines that drives cellular transformation is the loss of proper control of the mammalian cell cycle. The cyclin-dependent kinase inhibitor p21 (also known as p21 WAF1/Cip1) promotes cell cycle arrest in response to many stimuli.

In this review, we will focus on the multiple functions of p21 in cell cycle regulation, apoptosis and gene transcription after DNA damage and briefly discuss the pathways and factors that have critical roles in p21 expression and activity.

We propose strategies to use p21 for intervening in cellular senescence by delaying aging, eliminating senescent cells, and rejuvenating them. Understanding the pathogenesis of p21-dependent senescence is crucial for studying aging heterogeneity and …

Jun 1, 2016 · The inhibitory effect of P21 on cell cycle progression correlates with its nuclear localization. P21 can be induced by both p53-dependent and p53-independent mechanisms. Some other important functions attributed to p21 include transcriptional regulation, modulation or inhibition of apoptosis.

P21 is a peptide that targets neurogenesis and neurodegeneration. Studies show P21 rescued many structural deformities seen in the brains of autistic mice.

Feb 3, 2020 · Cyclin-dependent kinase inhibitor 1, also known as CDK-interacting protein 1, or more simply as p21, is a cell cycle inhibitor that promotes both CDK/cyclin inhibition as well as cell...

Aug 14, 2020 · p21 functions as a cell cycle inhibitor and anti-proliferative effector in normal cells, and is dysregulated in some cancers. Earlier observations on p21 knockout models emphasized the role of this protein in cell cycle arrest under the p53 transcription factor activity.

Jan 1, 2017 · Cell cycle–inhibitory function of p21. The p21 gene is a transcriptional target for multiple proliferation-inhibitory signaling cascades, including p53 (which can be activated in response to DNA damage), TGF (transforming growth factor beta), TNF (tumor necrosis factor alpha), IFN (interferon gamma), or APC (adenomatosis polyposis coli). p21 ...