The Th2-type cytokines include interleukins 4, 5, and 13, which are associated with the promotion of IgE and eosinophilic responses in atopy, and also interleukin-10, which has more of an anti-inflammatory response. In excess, Th2 responses will counteract the …

Jun 17, 2019 · The main difference between TH1 and TH2 immune response is that TH1 immune response is a proinflammatory response, which kills intracellular parasites and perpetuates autoimmune responses, whereas TH2 immune response promotes IgE and eosinophilic responses in atopy and produces anti-inflammatory responses, which kill large, extracellular ...

Sep 20, 2024 · Explore the distinct roles and mechanisms of Th1 and Th2 responses, their cytokine profiles, and implications in autoimmune and allergic diseases. The immune system’s ability to differentiate between various pathogens and mount an appropriate response is crucial for maintaining health.

In this review, we will discuss some recent interesting advances towards understanding the Th1/Th2 effector cell “choice”, particularly during in vivo immune responses, which include the role of new players in the transcriptional network, the contributions of dendritic cells (DCs) and innate lymphoid cells (ILCs) in the initiation of T cell ...

Dec 15, 2022 · Th1 cells drive the so-called type-1 pathway (“cellular immunity”). They are thought to be involved in fighting viruses and other pathogens that enter cells, getting rid of cancerous cells, and triggering delayed-type hypersensitivity (DTH) skin reactions. Th2 cells drive the type-2 pathway (“humoral immunity”).

Here we focus on how antigen interacts with the cells of the immune system to determine whether antigen predominantly generates Th1 or Th2 cells. We refer to this mechanism as the ‘decision criterion’ controlling the Th1/Th2 phenotype of the immune response.

CD4+ T helper cells regulate appropriate cellular and humoral immune responses to a wide range of pathogens and get involved in many diseases progress. The balance of the earliest determined CD4+ T helper cell subsets, Th1 and Th2, play an important role in …

Oct 19, 2000 · Th1 cells produce interleukin (IL)-2, interferon-γ (IFN-γ) and lymphotoxin-β, which mediate pro-inflammatory functions critical for the development of cell-mediated immune responses, whereas...

Mar 12, 2025 · Th1 cytokines help regulate immune responses, balancing pathogen defense and inflammation through complex signaling and interactions with other immune components. T-helper 1 (Th1) cytokines coordinate immune defenses against intracellular pathogens like viruses and certain bacteria.

The recognition of the polarized T helper cell subsets Th1 and Th2 has led to an understanding of the role of these cells in coordinating a variety of immune responses, both in responses to pathogens and in autoimmune and allergic disease.