Graded enhancement of p53 binding to CREB-binding protein …
Oct 20, 2010 · We investigated the role of single site and multiple site phosphorylation of the p53 transactivation domain in mediating its interaction with CBP and with the ubiquitin ligase …
p53 Recruitment of CREB Binding Protein Mediated through …
We propose that phosphorylated CREB mediates recruitment of CBP to p53-responsive promoters through direct interaction with p53. These observations provide evidence for a novel …
p53-independent tumor suppression by cell-cycle arrest via CREB…
May 30, 2023 · Saito et al. demonstrate that OASIS is a critical cell-cycle inhibitor and acts as a functional counterpart to tumor suppressor p53. Recovery of the inhibited OASIS expression in …
The transcription factor CREBZF is a novel positive regulator of p53
CREBZF was identified in a yeast two-hybrid screen using HEY1, recently characterized as an indirect p53 activator, as bait. CREBZF interacts in vitro with both HEY1 and p53, and …
p53 recruitment of CREB binding protein mediated through
We propose that phosphorylated CREB mediates recruitment of CBP to p53-responsive promoters through direct interaction with p53. These observations provide evidence for a novel …
p53 regulates ERK1/2/CREB cascade via a novel SASH1/MAP2K2 …
Apr 6, 2017 · In this study, we aimed to investigate the molecular mechanism undergirding hyperpigmentation in the dyschromatosis disorder. Our results revealed that SASH1 binds with …
Transcriptional regulation of tumor suppressor p53 by cAMP
In this study, we found that cAMP-responsive element-binding protein (CREB) collaborates with AMP-activated protein kinase alpha (AMPKalpha) to regulate the transcription of p53.
p53-independent tumor suppression by cell-cycle arrest via CREB…
May 30, 2023 · CREB/ATF transcription factor OASIS/CREB3L1 is upregulated in long-term-cultured astrocytes undergoing cell-cycle arrest due to loss of DNA integrity by repeated …
Binding of p53 to the KIX Domain of CREB Binding Protein
The pleiotropic cellular coactivator CREB binding protein (CBP) plays a critical role in supporting p53-dependent tumor suppressor functions. p53 has been shown to directly interact with a …
CREB represses p53-dependent transactivation of MDM2 through …
Mar 4, 2011 · In this study, we have found that CREB forms a complex with p53 and represses p53-mediated transactivation of MDM2 but not of p21WAF1. Immunoprecipitation analysis …
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