Cyclin D1 is a regulatory subunit of cyclin-dependent kinases CDK4 and CDK6. The protein dimerizes with CDK4/6 to regulate the G1/S phase transition and entry into the S-phase. CDK dependent functions

Cyclin D1 is mostly known for the role played in the nucleus, as regulator of cell cycle progression. Cyclin D1 modulates the transition from G1 to S phase through its action as allosteric regulator of the cyclin-dependent kinase 4 (CDK) and CDK6.

The critical role of cyclin D1-CDK4 in regulating cell cycle progression and the hyperactivation of cyclin D1-CDK4 in human tumors makes this complex an attractive target for cancer treatment. Cyclin D1 does not possess enzymatic activity, making it a challenging therapeutic target.

Cyclin D1 is an important regulator of cell cycle progression and overexpression of cyclin D1 has been linked to the development and progression of cancer. Deregulated cyclin D1 expression is also linked to the development of resistance to hormone therapy in breast cancer.

Mar 30, 2025 · Complete information for CCND1 gene (Protein Coding), Cyclin D1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

Cyclin D is a member of the cyclin protein family that is involved in regulating cell cycle progression. The synthesis of cyclin D is initiated during G1 and drives the G1/S phase transition.Cyclin D protein is anywhere from 155 (in zebra mussel) to 477 (in Drosophila) amino acids in length. [2]Once cells reach a critical cell size (and if no mating partner is present in …

Cyclin D1 functions in regulation of progression of the cell cycle through the G1 to S phase and in cellular metabolism (Fu, Wang, Li, Sakamaki, & Pestell, 2004). Cyclin D1 plays an essential role in mammary gland development, where it is required for normal lobuloalveolar development.

Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the retinoblastoma protein and promotes progression through the G1-S phase of the cell cycle. Amplification or overexpression of cyclin D1 plays pivotal roles in the development of a subset of human cancers …

Activation of the cyclin D1 oncogene, often by amplification or rearrangement, is a major driver of multiple types of human tumors including breast and squamous cell cancers, B-cell lymphoma, myeloma and parathyroid adenoma.

This review discusses cyclin D1 transcriptional, translational, and post-translational regulations and its biological function with a particular focus on the mechanisms that result in its dysregulation in human cancers.