The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins …

Mar 30, 2025 · CCND2 (Cyclin D2) is a Protein Coding gene. Diseases associated with CCND2 include Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 3 and …

Cyclin D is a member of the cyclin protein family that is involved in regulating cell cycle progression. The synthesis of cyclin D is initiated during G1 and drives the G1/S phase …

We describe herein that adult mice mutated in the cell cycle regulatory gene Ccnd2, encoding cyclin D2, lack newly born neurons in both of these brain structures. In contrast, genetic …

In this review, we will summarize and compare the roles played by each D-type cyclin during development and provide examples of how their intracellular dysregulation can be an …

Cyclin D2's role in the cell division cycle makes it a key controller of the rate of cell growth and division (proliferation) in the body. The cyclin D2 protein is regulated by a chemical signaling …

Feb 8, 2025 · our results demonstrate that cyclin D2 has a critical role in cell cycle progression and the tumorigenicity of glioblastoma stem cells; Cyclin D2 is a direct target of miR-206 in …

Cyclin D2 is a downstream target of c-Myc and RUNX1/ETO oncogenes [42, 43]. Hyperactivation of proto-oncogenic signaling by these oncogenic factors accelerates cell cycle progression in …

Sep 10, 2012 · Here we show that cyclin D2 is the cyclin that is predominantly expressed in GSCs and suppression of its expression by RNA interference causes G1 arrest in vitro and growth …

In response to the ligand-mediated activation of cytokine receptors, cells decide whether to proliferate or to undergo differentiation. D-type Cyclins (Cyclin D1, D2, or D3) and their …