Deficiency of ATF3 facilitates both angiotensin II‐induced and ...
Dec 27, 2024 · Our study indicates that ATF3 is essential for genomic DNA stability in VSMCs through the P21–cGAS–STING pathway, suggesting that enhancing ATF3 expression in VSMCs could help prevent sporadic AAD. ATF3 deficiency led to degradation of P21 through ubiquitination, which abolished the G1 phase arrest.
β-arrestin 2 as an activator of cGAS-STING signaling and target …
Nov 26, 2020 · Here we demonstrate that β-arrestin 2 also promotes virus-induced production of IFN-β and clearance of viruses in macrophages. β-arrestin 2 interacts with cyclic GMP-AMP synthase (cGAS) and increases the binding of dsDNA to cGAS to enhance cyclic GMP-AMP (cGAMP) production and the downstream stimulator of interferon genes (STING) and innate ...
The role of the MDM2/p53 axis in antitumor immune responses
Jul 23, 2024 · Mouse double minute 2 homolog (MDM2) is a negative regulator of the tumor suppressor p53 and is often highly expressed in acute myeloid leukemia (AML) and other solid tumors.
METTL3-mediated N6-methyladenosine modification stimulates ...
Nov 5, 2023 · METTL3-mediated N6-methyladenosine modification stimulates mitochondrial damage and ferroptosis of kidney tubular epithelial cells following acute kidney injury by modulating the stabilization of MDM2-p53-LMNB1 axis
Targeting MDM2 in malignancies is a promising strategy for …
Jan 29, 2024 · MDM2 provokes immune tolerance in malignancies, resulting in insensitivity to anticancer immunotherapy. MDM2 is widely expressed in various types of malignancies, making it a potential tumor-associated antigen (TAA).
Molecular mechanisms and cellular functions of cGAS–STING ... - Nature
May 18, 2020 · Here, we review the molecular mechanisms and cellular functions underlying cGAS–STING activation and signalling, particularly highlighting the newly emerging diversity of this signalling pathway...
arrestin 2 interacts with cyclic GMP-AMP synthase (cGAS) and increases the binding of dsDNA to cGAS to enhance cyclic GMP-AMP (cGAMP) production and the downstream stimulator of interferon genes...
Targeting activation of cGAS-STING signaling pathway by …
Sep 1, 2024 · Among them, the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) signaling pathway is vitally important for activating innate and adaptive antitumor immunity.
The cGAS–STING, p38 MAPK, and p53 pathways link genome …
Our findings reveal that the rapid senescence of Atm −/− lung fibroblasts is driven by the collaborative action of the cGAS–STING, p38 MAPK, and p53 pathways in response to persistent DNA damage, ultimately leading to the induction of interferon-α1 and downstream interferon-stimulated genes.
Abstract B003: cGAS inhibits TP53 and prevents DLBCL cell lines …
Mar 11, 2025 · Mechanically, cGAS inhibits tumor suppressor TP53 protein expression and prevents DLBCL cell lines from undergoing ferroptosis. cGAS knockout leads to a rescue of TP53 and a decrease of MDM2, which sensitizes cells to ferroptosis.