Mdm2 has been identified as a p53 interacting protein that represses p53 transcriptional activity. Mdm2 achieves this repression by binding to and blocking the N-terminal trans-activation …

The MDM2 gene was discovered as one of three genes (MDM1, MDM2, and MDM3) within an amplicon cloned from the tumorigenic mouse cell line 3T3DM (1–3). The genes have different …

MDM2 is an oncogene that is frequently over-expressed in various human cancers, including sarcomas, gliomas, melanomas, and breast cancers. 1 The primary function of MDM2 is to …

Mar 30, 2025 · MDM2 (MDM2 Proto-Oncogene) is a Protein Coding gene. Diseases associated with MDM2 include Lessel-Kubisch Syndrome and Accelerated Tumor Formation. Among its …

The murine double minute 2 (MDM2) gene (also referred to as human double minute 2 (HDM2)) is well recognized for its growth-promoting role in various cancers . The pathogenic role of …

May 13, 2024 · Studies have shown that in 5.9% of breast cancer patients, the MDM2 gene was amplified approximately 17-fold in tumor cells, and there were post-translational modified …

Dec 1, 2003 · Abstract. The murine double minute 2 (mdm2) gene encodes a negative regulator of the p53 tumor suppressor. Amplification of mdm2 or increased expression

MDM2 is an oncoprotein that blocks p53 tumor suppressor-mediated transcriptional transactivation, escorts p53 from the cell nucleus to the cytoplasm, and polyubiquitylates p53. …

Feb 17, 2025 · This review aims to provide an overview of MDM2 and MDM4, by assessing gene and protein structure and implications for protein-protein interactions and functions in cell and …

The MDM2 gene encodes an E3 ubiquitin-protein ligase that mediates the ubiquitination of p53, leading to its degradation. MDM2 enhances tumour formation by inactivating the p53 tumour …