Jun 14, 2023 · These are the key histologic features of dedifferentiated liposarcoma. Detection of MDM2 amplification by FISH is a useful ancillary tool to confirm the diagnosis of both well …

The MDM2 gene and its neighboring gene CDK4 are amplified, which can be detected by molecular methods such as reverse transcription–polymerase chain reaction (RT-PCR) and …

MDM2 amplification represents the leading oncogenic pathway and diagnostic hallmark of liposarcoma, whose assessment is based on Fluorescence In Situ Hybridization (FISH) analysis.

MDM2 (BSB-64) is a mouse monoclonal antibody (MMab) for immunohistochemistry from Bio SB. Used to distinguish dedifferentiated liposarcoma (positive) from poorly differentiated sarcomas …

MDM2 (located at 12q15) codes for an oncoprotein of which the association with p53 was discovered 30 years ago. The protein functions as an E3 ubiquitin ligase that targets the p53 …

Fluorescent in situ hybridization (FISH) for amplification of MDM2 has been considered the gold standard for diagnosis in these situations. Immunostaining for MDM2 and/or CDK4 has been …

Jan 22, 2025 · MDM2 IHC is used to detect overexpression of MDM2. A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type or one (1) unbaked, unstained slide …

To analyze the utility and limitations of ancillary techniques, we studied 11 cases of DDLPS in challenging conditions and 17 cases of nonlipogenic high-grade sarcomas with …

Atypical lipomatous tumor and dedifferentiated liposarcoma. Clearly indicate clinical reason for testing provide the following information: differential diagnosis, site of specimen, and clinical …

Detection of MDM2/CDK4 protein overexpression by IHC can be used by pathologists to diagnose WDLPS and DDLPS. Considering a strong and diffuse immunostaining pattern in most of the …