Nutlins are cis - imidazoline analogs which inhibit the interaction between mdm2 and tumor suppressor p53, and which were discovered by screening a chemical library by Vassilev et al. …

Nutlin-3 binds to the p53 binding pocket in MDM2 and inhibits the p53/MDM2 interaction, leading to stabilization of p53 and induction of p53-dependent cell cycle arrest or apoptosis. Nutlin-3 …

Jun 29, 2010 · Nutlin-3 is a small-molecule inhibitor that binds preferentially to the p53-binding pocket of MDM2, leading to stabilisation of p53 and activation of the p53 pathway.

Treatment with nutlin-3 results in a rapid accumulation of p53 protein, within 1–2 h of treatment, and in a robust induction of p53 target gene expression in neuroblastoma cells with wild-type …

Mar 19, 2013 · Induction of cellular senescence through activation of the p53 tumor suppressor protein is a new option for treating proliferative disorders. Nutlins prevent the ubiquitin ligase …

Oct 11, 2022 · Nutlin-3 DrugBank Accession Number DB17039 Background. Nutlin-3 is a small molecule inhibitor that targets p53-Mdm2 interaction. 1. Type Small Molecule Groups …

Nutlin-3 is a small-molecule inhibitor that binds preferentially to the p53-binding pocket of MDM2, leading to stabilisation of p53 and activation of the p53 pathway.

Nutlin-3, a small molecule inhibitor that specifi-cally targets p53-Mdm2 interaction offers new therapeutic opportunities by enhancing cancer cell growth arrest and apoptosis through the …

Oct 17, 2013 · Nutlin-3 is a potent enhancer of D269H/E195R-induced apoptosis in wild-type p53-expressing cancer cells. Addition of DNA-damaging agents such as cisplatin further enhances...

Nutlin-3 is a small molecule inhibitor of the MDM2/p53 interaction, which leads to the non-genotoxic p53 stabilization, activation of cell cycle arrest and apoptosis pathways. A series of …