This review focuses on p16, a crucial biomarker of cell senescence and molecular aging, the methodology of p16 measurement in humans, and the utility of p16 expression in guiding …

Nov 2, 2011 · To address these fundamental questions, we made use of a biomarker for senescence, p16 Ink4a, to design a novel transgene, INK-ATTAC, for inducible elimination of …

Extensive research has revealed that p16 expression is significantly increased in senescent cells, as well as during natural aging or age-related pathologies. Based on this fact, p16 is …

Nov 11, 2024 · Overall, our findings indicate that social stress induces an organ-specific and p16Ink4a -dependent accumulation of senescent cells, illuminating a fundamental way by …

Cellular senescence can be triggered by a number of factors including, aging, DNA damage, oncogene activation and oxidative stress. While the molecular mechanism of senescence …

Dec 20, 2024 · Biomarkers of aging have drawn attention as a means to better understand aging and its effects on older adults with cancer. The gene p16INK4a (p16) codes for a protein that …

The tumor suppressor protein p16 INK4a (p16) is a well-established hallmark of aging that induces cellular senescence in response to stress. Previous studies have focused primarily on …

Jan 23, 2024 · P16 is a tumor suppressor and cell cycle regulator that has been linked to aging and senescence. Extensive research has revealed that p16 expression is significantly …

Nov 2, 2011 · Here we show that in the BubR1 progeroid mouse background, INK-ATTAC removes p16 (Ink4a)-positive senescent cells upon drug treatment. In tissues--such as …

In murine models, p16 expression reflects biologic aging in almost all organs. Preliminary findings in patients with cancer support p16 measurement as a marker of physiologic aging and …