Jul 18, 2018 · There is evidence that p21 negatively regulates proliferation of neural progenitors (NPCs). Here we characterized the effects of p21 on disruption of neuronal development in the...

Peptide P21 reverses Autistic neurodegeneration while improving cognition, memory, and reasoning through new neuron formation in the brain.

We examined expression of senescence (p16 and p21) and DNA damage markers (8-OHdG and γH2AX) in motor cortex (MCx), frontal association cortex (FACx) and occipital cortex (OCx) in …

We propose strategies to use p21 for intervening in cellular senescence by delaying aging, eliminating senescent cells, and rejuvenating them. Understanding the pathogenesis of p21 …

Parent Protein (CNTF) of P21 Peptide Rescues Dopamine Neurons. “Ciliary neurotrophic factor (CNTF) has a neuroprotective effect on dopaminergic neurons. Nam et al. report that the …

Sep 5, 2023 · P21’s likely ability to traverse the blood-brain barrier without provoking immune responses adds to its appeal in extensive areas of research. As investigations into P21 …

It was fully rescued by loss of p21 (CDKN1A) function in late-generation TERC-/-CDKN1A-/- mice, indicating p21 as the necessary signal transducer between DNA damage response and …

Jan 3, 2013 · Cyclin-dependent kinase inhibitor 1A (p21) directly targets Sox2 to regulate cell cycle progression and drive adult neural stem cell expansion.

The serine/threonine p21-activated kinases (PAKs), as main effectors of the Rho GTPases Cdc42 and Rac, represent a group of important molecular switches linking the complex cytoskeletal …

Expression of p16 and p21 in glia, mainly in astrocytes, suggests senescence induction in these cells; however, neuronal p21 expression might reflect a more general mechanism of age …