MAGT1 is required for HeLa cell proliferation through regulating p21 …
We showed that cell proliferation was substantially restricted by S-phase arrest and apoptosis in the MAGT1-knocked down cells, which was further confirmed by the increased expression of …
Investigating the p21 Ubiquitin-Independent Degron Reveals a …
Oct 9, 2024 · To demonstrate the role of this box in p21 degradation, we edited the genome of HEK293 and HeLa cell lines using a CRISPR strategy. We found that the p21 half-life …
MAGT1 is required for HeLa cell proliferation through regulating p21 …
We showed that cell proliferation was substantially restricted by S-phase arrest and apoptosis in the MAGT1-knocked down cells, which was further confirmed by the increased expression of …
Regulation of p21/CIP1/WAF-1 mediated cell-cycle arrest by …
We found a significant loss of p21 mRNA expression in RNASEL−/− MEFs and that the overexpression of RNase L in HeLa cells induces p21 mRNA expression. The p21 mRNA half …
Functional Role of p21 During the Cellular Response to Stress
HeLa cells were infected with either Ad.null (an adenovirus carrying no insert) or Ad.p21 (an adenovirus expressing a p21 cDNA), with a virus dose of 100 plaque-forming units (pfu)/cell …
The cGAS/STING/TBK1/IRF3 innate immunity pathway maintains
Apr 13, 2020 · Signaling through cGAS, a protein that detects DNA in the cytosol, prevents chromosome instability (CIN) in cancer cells by regulating the levels of the cell-cycle inhibitor p21.
Regulation of p21/CIP1/WAF-1 mediated cell-cycle arrest by ... - PubMed
We found a significant loss of p21 mRNA expression in RNASEL (-/-) MEFs and that the overexpression of RNase L in HeLa cells induces p21 mRNA expression. The p21 mRNA half …
Analysis of p21 expression in Hela and U2OS cell lines
Western Blot analysis showed that the level of p21 expression in treated Hela and U2OS cells is higher compared to the controls ( Figure 5). This suggests the involvement of p21 protein in...
Transcriptional regulation of the cyclin-dependent kinase inhibitor 1A ...
Nov 27, 2006 · By conducting both ligation-mediated PCR (LMPCR) and chromatin immunoprecipitation (ChIP) in vivo, we identified a functional target site for the transcription …
Human NDR Kinases Control G1/S Cell Cycle Transition by Directly ...
Our findings suggest that NDR kinases control protein stability of the cyclin-Cdk inhibitor protein p21 by direct phosphorylation. These findings establish a novel MST3-NDR-p21 axis as an …