p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory transcription factor protein that is often mutated in human cancers.

Vastly studied biological processes where p53 has been shown to play a role are cell cycle arrest, senescence, DNA repair, and apoptosis (Figure 1).

Approximately half of all cancers have p53 inactivating mutations, in addition to which most malignancies inactivate the p53 pathway by increasing p53 inhibitors, decreasing p53 activators, or inactivating p53 downstream targets. ... Tumor suppressor p53-mediated cell cycle arrest, apoptosis, and senescence influence cancer progression .

Mar 1, 2019 · Activated p53 transcriptionally regulates hundreds of genes that are involved in multiple biological processes, including in DNA damage repair, cell cycle arrest, apoptosis and senescence.

p53, originally identified as a protein associated with the simian virus 40 large T antigen in 1979 (1–4), guards genomic integrity via regulating numerous cellular processes, including cell cycle arrest, DNA repair, apoptosis, and cellular senescence, in response to …

Nov 17, 2017 · In this review we discuss current understanding of the mechanisms by which p53 induces cell death and how this affects p53-mediated tumour suppression and the response of malignant cells to...

May 9, 2024 · Here, we review the complexity of different layers of p53 regulation, and the recent advance of the p53 pathway in metabolism, ferroptosis, immunity, and others that contribute to tumor suppression.

Feb 10, 2025 · The p53 signaling pathway is essential for maintaining cellular integrity and preventing tumorigenesis by regulating cell cycle progression, DNA repair, apoptosis, and senescence. Known as the “guardian of the genome,” it responds to various stress signals, ensuring damaged cells do not proliferate uncontrollably.

The p53 tumor suppressor protein plays a key role in the regulation of the cell cycle and cell death. The p53 protein is also involved in cell differentiation, DNA repair, senescence and angiogenesis. 1–8 Wild-type (wt) p53 and intact signaling pathways are essential for the prevention of cancer, consistent with a high tumor incidence ...

2 days ago · p53, a well-known important tumor suppressor, is central for regulating cell cycle in response to DNA damage and altered metabolism. 1 With a short half-life, p53’s stability and activity are ...