Mar 21, 2024 · Here, we use a mouse model of the human XPF-ERCC1 progeroid syndrome (XFE) caused by loss of DNA repair. We find that p53, a central regulator of the cellular …

Mouse models with activated p53, no p53, and mutant p53 have queried the role of p53 in development and tumorigenesis. In these models, p53 is activated and stabilized via …

In HCT116 cells and in mouse tissues, we did not observe 3′UTR-dependent differences in p53 mRNA or protein levels under normal conditions or after DNA damage. These results suggest …

The p53-deficient mice have been particularly valuable in examining the effects of p53 loss on tumor progression. In addition, the mice hold significant promise as tools to assess …

Mouse double minute 2 (MDM2) is a key negative regulator of the tumor suppressor p53 protein, inhibiting p53 protein activity and decreasing p53 concentration through a p53-MDM2 …

Feb 18, 2025 · Mouse models to investigate in situ cell fate decisions induced by p53. P53 Alleviates the Progression of Periodontitis by Reducing M1-type Macrophage Differentiation. …

Jan 14, 2013 · Here, we review studies utilizing p53 mutant mice that have recapitulated and informed clinical observations. These studies have demonstrated the p53 contribution, …

Sep 24, 2009 · As expected, mice that have mutant Trp53 alleles usually develop cancers of various types more rapidly than their counterparts that have wild-type Trp53 genes. These …

Here, we discuss how genetically engineered mouse models have been used to explore antiproliferative functions of p53 in cancer suppression and how mouse models with altered …

Sep 17, 2020 · High confidence p53 binding peaks identified in (A) mouse and (B) human and their conservation or the lack thereof in the human and mouse genomes, respectively.