p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory transcription factor protein that is …

TP53 is a gene that encodes for the p53 tumor suppressor protein, commonly referred to as the “Guardian of the Genome” [1]. Its main biological function appears to involve the protection of …

Jan 21, 2025 · What is TP53 and what role does it play in cancer? The TP53 gene is a gene that is mutated in many cancers. It is the most common gene mutation found in cancer cells. A …

Mar 1, 2023 · Accumulating evidence has shown that p53 also regulates cell metabolism, ferroptosis, tumor microenvironment, autophagy and so on, all of which contribute to tumor …

Drugs targeting p53 achieve tumor suppression by activating p53, restoring the wild-type conformation of p53, and reducing ubiquitination of p53. Targeting TME has advantages over …

Nov 18, 2022 · Emerging evidence suggests that mutp53 is highly associated with advanced malignancies and poor prognosis, which makes it a target for development of novel cancer …

Discovered in 1979, the p53 protein, encoded by the tumor protein p53 (TP53, or p53) gene, has captivated the attention of both the cancer research community and the pharmaceutical …

Dec 24, 2021 · In contrast to its wild-type counterpart, mutant p53 in cancer cells regulates and inhibits the tumor-suppressive response to IFN-β via inhibiting STAT1 phosphorylation and …

TP53 is the most commonly mutated gene in human cancer with over 100,000 literature citations in PubMed. This is a heavily studied pathway in cancer biology and oncology with a history …

Mar 19, 2025 · Figure 1. p53 and the tumor microenvironment. p53 can inhibit tumor development by suppressing the inflammatory response. In tumor-associated T cells, p53 inhibits the …