May 28, 2020 · p21^Waf/CIP1 is a small unstructured protein that binds and inactivates cyclin-dependent kinases (CDKs). To this end, p21 levels increase following the …

CDK inhibition by p21 triggers cell-cycle arrest in the G1 and G2 phases of the cell cycle. In the absence of exogenous insults causing replication stress, only residual p21 levels are prevalent …

Apr 2, 2019 · Through mathematical modeling and genome engineering, we show that the underlying molecular mechanism depends on the interaction of PCNA and p21 during S phase …

Dec 15, 2008 · Interestingly, both the cyclin dependent kinase (CDK) and proliferating cell nuclear antigen (PCNA) binding domains of p21 are involved in different aspects of the modulation of …

Jun 1, 2016 · In addition, p21 can play a role in DNA repair by interacting with proliferating cell nuclear antigen (PCNA). In this review, we will focus on the multiple functions of p21 in cell …

Our findings showing that PARP-1 binds both PCNA and p21, and that both interactions increase upon DNA damage, suggest that in vivo PARP-1, PCNA and p21 undergo a dynamic …

We propose a novel model in which CRL4 CDT2 -dependent protein degradation facilitates a sequential and dynamic exchange between PIP box-bearing proteins at stall forks during …

Oct 14, 1997 · The crystal structure of the human DNA polymerase delta processivity factor PCNA (proliferating cell nuclear antigen) complexed with a 22 residue peptide derived from the …

p21 interacts with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. [17][18][19] …

Apr 2, 2019 · Shape-based clustering revealed that the dynamics of the CDK inhibitor p21 diverges from the dynamics of its transcription factor p53 during S phase. Using mathematical …