Regulation of MYC gene expression by aberrant Wnt/β-catenin …
Deregulated expression of the c-MYC proto-oncogene (MYC) by aberrant Wnt/β-catenin signaling drives colorectal carcinogenesis. In this review, we discuss the current literature pertaining to …
Wnt/β-catenin signaling pathway upregulates c-Myc expression …
The results showed that SB216763 induced the nuclear translocation of β-catenin, upregulated the expression of c-myc and pluripotency related genes, oct4, sox2 and nanog, and blocked …
Canonical Wnt Signaling (Wnt/β-Catenin Pathway): A Potential …
This gene is one of the most potent cellular proto-oncogenes and encodes c-Myc protein. c-Myc is a transcription factor that binds to DNA (via helix-loop-helix and leucine zipper domains) and …
Wnt/β-catenin signalling: function, biological mechanisms, …
Jan 3, 2022 · sFRPs, WIF, glypicans, Tiki, and Notum are well-known regulators of Wnt/β-catenin signalling that target Wnt proteins to affect signal transduction. sFRPs have a Netrin-related …
Canonical WNT signaling-dependent gating of MYC requires a
Jan 11, 2022 · We show here that the principal tenet of the WNT-regulated MYC gating, facilitating nuclear export of the MYC mRNA, is regulated by a CTCF binding site (CTCFBS) …
Wnt signaling promotes oncogenic transformation by inhibiting c-Myc ...
Using an inducible c-MycER expression system, we found that Wnt/β-catenin signaling suppressed apoptosis by inhibiting c-Myc–induced release of cytochrome c and caspase …
Wnt signaling in cancer: from biomarkers to targeted therapies …
Apr 2, 2025 · Elevated c-Myc levels in tumor cells are a strong indicator of aggressive tumor behavior [146, 147], particularly in cases where Wnt pathway activation is involved [148, 149]. …
Chronological expression of Wnt target genes Ccnd1, Myc ... - PubMed
Here we present the expression chronologies of the target genes Ccnd1 (encoding for cyclin D1), Myc (c-Myc), Cdkn1a (p21CIP1/WAF1), Tfrc (Transferrin receptor 1), Plf1 (Proliferin-1) and …
WNT/β-catenin-suppressed FTO expression increases m6A of c-Myc …
May 8, 2021 · In this study, we demonstrate that Wnt signaling induces complex formation between the histone methyltransferases EZH2 and β-catenin, which bind to the promoter …
Wnt/β‐Catenin Signaling Pathway Upregulates c‐Myc Expression …
Sep 14, 2012 · C-myc mediates the effects of Wnt/β-catenin signaling on P19 cell proliferation and differentiation. A: Western-blotting analysis for c-myc protein levels after siRNA …