Nuclear myosin 1 activates p21 gene transcription in response to …
Mar 11, 2020 · In addition, chromatin immunoprecipitation sequencing (ChIP-seq) and ChIP quantitative PCR (qPCR) experiments show that NM1 is enriched at the transcription start site …
p21 as a Transcriptional Co-Repressor of S-Phase and Mitotic …
The mRNA expression of p21 (upper graph) and p27 (lower graph) was determined by RT-qPCR 24 h after infection. Data are represented relative to the expression in Ad-GFP-infected cell. B. …
A dual role of RBM42 in modulating splicing and translation of
Nov 22, 2023 · Herein, we identify the human RNA binding motif protein 42 (RBM42) as a regulator of p21 levels during DNA damage. Genome-wide transcriptome and interactome …
Age-specific functional epigenetic changes in p21 and p16 in …
Here we uncover key age-specific differences underlying this proliferative decline: namely, the genetic loci of CDK inhibitors (CDKI) p21 and p16 are more epigenetically silenced in young …
cyclin-dependent kinase inhibitor p21 is regulated by RNA …
Sep 3, 2010 · We found that PCBP4 expression decreases cyclin-dependent kinase inhibitor p21 induction in response to DNA damage. We also provided evidence that PCBP4 regulates p21 …
Transcription regulation of CDKN1A (p21/CIP1/WAF1) by TRF2 is …
Sep 14, 2017 · We observed extra-telomeric binding of the telomere repeat binding factor TRF2 within the promoter of the cyclin-dependent kinase CDKNIA (p21/CIP1/WAF1). This result in …
p21 produces a bioactive secretome that places stressed cells …
Our study illuminates that immediate-early cell-autonomous reactions to cellular stress are coordinated with cell non-autonomous responses through p21-mediated changes in the Rb …
LincRNA-p21 activates p21 in cis to promote Polycomb target …
Jun 5, 2014 · LincRNA-p21 acts with hnRNP-K as a transcriptional co-activator of p53-mediated expression of p21 (A) Schematic of the positions of qPCR primers used for ChIP analysis, …
FAM13A regulates cellular senescence marker p21 and ... - PubMed
Aug 22, 2023 · Protein levels of FAM13A and cellular senescence marker p21 were investigated using immunohistochemistry in lung tissue from patients with COPD. In vitro, FAM13A and …
MDM2-Dependent Downregulation of p21 and hnRNP K Provides …
Mar 3, 2009 · We uncovered that MDM2 released from p53 by RITA promotes degradation of p21 and the p53 cofactor hnRNP K, required for p21 transcription. Functional studies revealed …